Prostaglandin-induced diarrhoea.

Mycophenolate induced diarrhoea.

Mycophenolate (MMF) has arisen as an important addition in the immunosuppression armamentarium. GI disturbances (diarrhea) and bone marrow suppression are its main side effects requiring dose reduction or even withdrawal. The mechanism of diarrhoea is unknown, although some theories have been postulated. We evaluated three of our patients on MMF who came to us with chronic diarhoea. Their evalu...

Bile Acid Induced Diarrhoea

Prostaglandin synthetase inhibitor in an infant with congenital chloride diarrhoea.

Hyper-reninaemia, hypokaluria, and hypokalaemia in an infant with congenital chloride diarrhoea improved during treatment with a prostaglandin synthetase inhibitor, ketoprofen. There was evidence of increased activity of therenin-aldosterone system when ketoprofen was stopped. It is suggested that prostaglandins may be involved in stimulating the renin-aldosterone system in congenital chloride ...

Investigation of auranofin-induced diarrhoea.

Gastrointestinal function was assessed in six patients with rheumatoid arthritis who had developed diarrhoea on treatment with Auranofin. With the administration of Auranofin whole gut transit time decreased markedly (to 50% or less of control values) in five of six patients. The speed of passage of intestinal contents through the colon was certainly increased but attempts to assess transit thr...

Sugar-induced diarrhoea in children.

In recent years there has been a proliferation of knowledge about normal and abnormal digestion and absorption of carbohydrates. Many of these advances have been made since Anderson's comments about sugar intolerance in her review of intestinal malabsorption in childhood published in this journal in 1966, and since Holzel's review of the problem in 1967. This review is not intended as a compreh...